Chronic Inflammatory Response Syndrome (CIRS): A Comprehensive Overview
Diagnosing CIRS: Making the Invisible Visible
A diagnosis involves more than symptoms—it’s grounded in patterns, lab markers, and environmental history.
Gold-Standard Tools Include:
HLA-DR Genotyping: Assesses immune recognition deficits.
VCS Testing: Screens for early neuroinflammation.
Biomarkers:
TGF-β1: Fibrosis and immune suppression.
MSH: Hormonal and immune regulator, often low.
C4a: Innate immune activation.
VEGF, VIP, MMP-9: Related to vascular health and tissue damage.
NeuroQuant MRI: Identifies specific brain volume changes.
GENIE Transcriptomics: Reveals molecular hypometabolism and proliferative physiology.
Treatment: A Map to Recovery
CIRS is treatable—often dramatically so—when interventions follow a precise, stepwise plan.
Core Elements of Healing Include:
Environmental Avoidance & Remediation
HERTSMI-2 or ERMI scoring to assess buildings.
Safe housing is essential; even small exposures can reignite symptoms.
Biotoxin Binding
Cholestyramine or Welchol bind toxins in bile and stop the inflammatory feedback loop.
Pathogen & MARCoNS Eradication
Treating nasal staph colonization that suppresses MSH.
Transcriptomic Repair
Use of VIP nasal spray has been shown to reverse gene suppression and support mitochondrial and ribosomal repair.
Supportive Therapies
Mitochondrial Repair: CoQ10, NAD+, and targeted nutrients.
Limbic System Retraining: DNRS, Gupta Program, and somatic therapies.
Anti-inflammatory Nutrition: Focus on low-histamine, whole foods rich in polyphenols and detox cofactors.
Hormonal & Immune Modulation: VIP, oxytocin, adaptogens, and MCAS support.
A Note to Those on the Path
If your body has been sounding alarms, it isn’t betraying you—it’s protecting you. Sensitivity is not weakness. It’s intelligence.
CIRS is not your fault. And you are not broken.
Healing takes time, layers, and support—but it is possible. You are not alone in this. Thousands have walked this path and emerged clearer, stronger, and more connected to their body’s wisdom than ever before.
As you move forward, remember: your symptoms are not random. They are meaningful. And now, finally, you have a map.